Integrating Duodenal Sampling in a Human Mass Balance Study to Quantify the Elimination Pathways of JNJ-53718678, a Respiratory Syncytial Virus Fusion Protein Inhibitor.

Remmerie, Bart; van den Boer, Maarten; Van Looy, Thomas; Wynant, Inneke; Rusch, Sarah; Huntjens, Dymphy; De Meulder, Marc; Stevens, Marita

Remmerie, Bart; van den Boer, Maarten; Van Looy, Thomas; Wynant, Inneke; Rusch, Sarah; Huntjens, Dymphy; De Meulder, Marc; Stevens, Marita.

Afiliación

Remmerie B; Global Clinical Pharmacology, Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium. bremmeri@its.jnj.com.
van den Boer M; Clinical Pharmacology Unit, Janssen Research & Development, Lange Bremstraat 70, 2170, Merksem, Belgium.
Van Looy T; Clinical Pharmacology Unit, Janssen Research & Development, Lange Bremstraat 70, 2170, Merksem, Belgium.
Wynant I; Drug Metabolism and Pharmacokinetics, Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
Rusch S; Statistical Decision and Sciences, Janssen Biostatistics Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
Huntjens D; Global Clinical Pharmacology, Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
De Meulder M; Drug Metabolism and Pharmacokinetics, Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
Stevens M; Global Clinical Development Infectious Diseases, Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.

Adv Ther ; 37(1): 578-591, 2020 01.

Article en En | MEDLINE | ID: mdl-31832988

Asunto(s)

Imidazolidinas/metabolismo; Indoles/metabolismo; Virus Sincitiales Respiratorios/metabolismo; Adulto; Animales; Área Bajo la Curva; Citocromo P-450 CYP3A/metabolismo; Humanos; Masculino; Tasa de Depuración Metabólica; Redes y Vías Metabólicas

Palabras clave

Duodenal fluid sampling; Infectious disease; JNJ-53718678; Mass balance; Respiratory syncytial virus

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Sincitiales Respiratorios / Imidazolidinas / Indoles Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Humans / Male Idioma: En Revista: Adv Ther Asunto de la revista: TERAPEUTICA Año: 2020 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos

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