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Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
Corte, James R; Pinto, Donald J P; Fang, Tianan; Osuna, Honey; Yang, Wu; Wang, Yufeng; Lai, Amy; Clark, Charles G; Sun, Jung-Hui; Rampulla, Richard; Mathur, Arvind; Kaspady, Mahammed; Neithnadka, Premsai Rai; Li, Yi-Xin Cindy; Rossi, Karen A; Myers, Joseph E; Sheriff, Steven; Lou, Zhen; Harper, Timothy W; Huang, Christine; Zheng, Joanna J; Bozarth, Jeffrey M; Wu, Yiming; Wong, Pancras C; Crain, Earl J; Seiffert, Dietmar A; Luettgen, Joseph M; Lam, Patrick Y S; Wexler, Ruth R; Ewing, William R.
Afiliación
  • Corte JR; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Pinto DJP; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Fang T; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Osuna H; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Yang W; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Wang Y; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Lai A; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Clark CG; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Sun JH; Research and Development , Bristol-Myers Squibb Company , US Rt. 206 & Province Line Road , Princeton , New Jersey 08540 , United States.
  • Rampulla R; Research and Development , Bristol-Myers Squibb Company , US Rt. 206 & Province Line Road , Princeton , New Jersey 08540 , United States.
  • Mathur A; Research and Development , Bristol-Myers Squibb Company , US Rt. 206 & Province Line Road , Princeton , New Jersey 08540 , United States.
  • Kaspady M; Bristol-Myers Squibb Research Center , Syngene International Pvt. Ltd. , Biocon Park, Plot No. 2 & 3, Bommasandra-Jigani Road , Bangalore 560 100 , India.
  • Neithnadka PR; Bristol-Myers Squibb Research Center , Syngene International Pvt. Ltd. , Biocon Park, Plot No. 2 & 3, Bommasandra-Jigani Road , Bangalore 560 100 , India.
  • Li YC; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Rossi KA; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Myers JE; Research and Development , Bristol-Myers Squibb Company , US Rt. 206 & Province Line Road , Princeton , New Jersey 08540 , United States.
  • Sheriff S; Research and Development , Bristol-Myers Squibb Company , US Rt. 206 & Province Line Road , Princeton , New Jersey 08540 , United States.
  • Lou Z; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Harper TW; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Huang C; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Zheng JJ; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Bozarth JM; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Wu Y; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Wong PC; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Crain EJ; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Seiffert DA; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Luettgen JM; Research and Development , Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road , Pennington , New Jersey 08543 , United States.
  • Lam PYS; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Wexler RR; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
  • Ewing WR; Research and Development , Bristol-Myers Squibb Company , 350 Carter Road , Hopewell , New Jersey 08540 , United States.
J Med Chem ; 63(2): 784-803, 2020 01 23.
Article en En | MEDLINE | ID: mdl-31833761
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Factor XIa / Fibrinolíticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Factor XIa / Fibrinolíticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos