Organoids for Liver Stage Malaria Research.
Trends Parasitol
; 36(2): 158-169, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31848118
ABSTRACT
Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans. 2D culture models provide extremely beneficial tools to investigate Plasmodium biology but they have limitations. More complex 3D structural networks, such as organoids, have unveiled new avenues for developing more physiological tissue models, and their application to malaria research offers great promise. Here, we review current models for studying Plasmodium infection with a key focus on the obligate pre-erythrocytic stage that culminates in blood infection, causing malaria, and discuss how organoids should fulfil an important and unmet need.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parasitología
/
Plasmodium
/
Organoides
/
Interacciones Huésped-Parásitos
/
Hígado
/
Malaria
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Parasitol
Asunto de la revista:
PARASITOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia