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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7.
Neff, Robert A; Flinspach, Mack; Gibbs, Alan; Shih, Amy Y; Minassian, Natali A; Liu, Yi; Fellows, Ross; Libiger, Ondrej; Young, Stephanie; Pennington, Michael W; Hunter, Michael J; Wickenden, Alan D.
Afiliación
  • Neff RA; Neuroscience Discovery, Janssen Research and Development, LLC, San Diego, California 92121 rneff@its.jnj.com.
  • Flinspach M; Biologics Research, Janssen Research and Development, LLC, San Diego, California 92121.
  • Gibbs A; Structural Biology, Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Shih AY; Discovery Chemistry-Computational Chemistry, Janssen Research and Development, LLC, San Diego, California 92121.
  • Minassian NA; Neuroscience Discovery, Janssen Research and Development, LLC, San Diego, California 92121.
  • Liu Y; Neuroscience Discovery, Janssen Research and Development, LLC, San Diego, California 92121.
  • Fellows R; Biologics Research, Janssen Research and Development, LLC, San Diego, California 92121.
  • Libiger O; Translational Medicine and Early Development Statistics, Janssen Research and Development, LLC, San Diego, California 92121.
  • Young S; Translational Medicine and Early Development Statistics, Janssen Research and Development, LLC, San Diego, California 92121.
  • Pennington MW; Peptides International, Inc., Louisville, Kentucky 40299.
  • Hunter MJ; Biologics Research, Janssen Research and Development, LLC, San Diego, California 92121.
  • Wickenden AD; Molecular and Cellular Pharmacology, Janssen Research and Development, LLC, San Diego, California 92121.
J Biol Chem ; 295(5): 1315-1327, 2020 01 31.
Article en En | MEDLINE | ID: mdl-31871053
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Araña / Canal de Sodio Activado por Voltaje NAV1.7 / Bloqueadores del Canal de Sodio Activado por Voltaje / Analgésicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Araña / Canal de Sodio Activado por Voltaje NAV1.7 / Bloqueadores del Canal de Sodio Activado por Voltaje / Analgésicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos