NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma.

Ma, Xiaomin; Qiu, Yumin; Zhu, Lihui; Zhao, Yunxue; Lin, Yueke; Ma, Dapeng; Qin, Zhenzhi; Sun, Caiyu; Shen, Xuecheng; Li, Tao; Han, Lihui

Ma, Xiaomin; Qiu, Yumin; Zhu, Lihui; Zhao, Yunxue; Lin, Yueke; Ma, Dapeng; Qin, Zhenzhi; Sun, Caiyu; Shen, Xuecheng; Li, Tao; Han, Lihui.

Afiliación

Ma X; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Qiu Y; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Zhu L; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Zhao Y; Department of Pharmacology, Shandong University School of Basic Medical Sciences, Jinan, 250012, China.
Lin Y; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Ma D; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Qin Z; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Sun C; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Shen X; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China.
Li T; Department of Gastroenterology, Provincial Hospital Affiliated with Shandong University, Jinan, 250021, China.
Han L; Shandong Provincial Key Laboratory of Infection & Immunology, Department of Immunology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, China. hanlihui@sdu.edu.cn.

J Mol Med (Berl) ; 98(2): 221-232, 2020 02.

Article en En | MEDLINE | ID: mdl-31872284

Asunto(s)

Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; Proteína Adaptadora de Señalización NOD1/metabolismo; Animales; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Carcinoma Hepatocelular/tratamiento farmacológico; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Regulación hacia Abajo; Fluorouracilo/farmacología; Fluorouracilo/uso terapéutico; Humanos; Neoplasias Hepáticas/tratamiento farmacológico; Ratones Desnudos; Proteína Adaptadora de Señalización NOD1/genética; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico; Proto-Oncogenes Mas; ARN Interferente Pequeño/genética; Transducción de Señal/efectos de los fármacos; Sorafenib/farmacología; Sorafenib/uso terapéutico; Familia-src Quinasas/metabolismo

Palabras clave

Chemosensitivity; Hepatocellular carcinoma; MAPK; NOD1; SRC

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Proteína Adaptadora de Señalización NOD1 / Neoplasias Hepáticas Límite: Animals / Humans Idioma: En Revista: J Mol Med (Berl) Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania

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