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Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins.
Heikkilä, Nelli; Vanhanen, Reetta; Yohannes, Dawit A; Saavalainen, Päivi; Meri, Seppo; Jokiranta, T Sakari; Jarva, Hanna; Mattila, Ilkka P; Hamm, David; Sormunen, Silja; Saramäki, Jari; Arstila, T Petteri.
Afiliación
  • Heikkilä N; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Vanhanen R; Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Yohannes DA; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Saavalainen P; Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Meri S; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Jokiranta TS; Medicum, Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
  • Jarva H; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Mattila IP; Medicum, Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
  • Hamm D; Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Sormunen S; Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Saramäki J; Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
  • Arstila TP; Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Eur J Immunol ; 50(5): 748-751, 2020 05.
Article en En | MEDLINE | ID: mdl-31872865
ABSTRACT
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Monocigóticos / Receptores de Antígenos de Linfocitos T alfa-beta / Regiones Determinantes de Complementariedad / Recombinación V(D)J Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2020 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Monocigóticos / Receptores de Antígenos de Linfocitos T alfa-beta / Regiones Determinantes de Complementariedad / Recombinación V(D)J Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2020 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY