Evolving Antibiotics against Resistance: a Potential Platform for Natural Product Development?
mBio
; 10(6)2019 12 24.
Article
en En
| MEDLINE
| ID: mdl-31874919
ABSTRACT
To avoid an antibiotic resistance crisis, we need to develop antibiotics at a pace that matches the rate of evolution of resistance. However, the complex functions performed by antibiotics-combining, e.g., penetration of membranes, counteraction of resistance mechanisms, and interaction with molecular targets-have proven hard to achieve with current methods for drug development, including target-based screening and rational design. Here, we argue that we can meet the evolution of resistance in the clinic with evolution of antibiotics in the laboratory. On the basis of the results of experimental evolution studies of microbes in general and antibiotic production in Actinobacteria in particular, we propose methodology for evolving antibiotics to circumvent mechanisms of resistance. This exploits the ability of evolution to find solutions to complex problems without a need for design. We review evolutionary theory critical to this approach and argue that it is feasible and has important advantages over current methods for antibiotic discovery.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Productos Biológicos
/
Farmacorresistencia Microbiana
/
Desarrollo de Medicamentos
/
Antibacterianos
Idioma:
En
Revista:
MBio
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos