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Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.
Yang, Jing-Hua; Wang, Xin-Yi; Zhou, Yi-Ping; Lu, Rong; Chen, Chin-Ho; Zhang, Meng-Han; Cheng, Yung-Yi; Morris-Natschke, Susan L; Lee, Kuo-Hsiung; Wang, Yun-Song.
Afiliación
  • Yang JH; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • Wang XY; The High School Affiliated to Yunnan Normal University, Kunming 650106, China.
  • Zhou YP; School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
  • Lu R; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • Chen CH; Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  • Zhang MH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Cheng YY; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Morris-Natschke SL; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan.
  • Lee KH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Wang YS; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Molecules ; 25(1)2019 Dec 26.
Article en En | MEDLINE | ID: mdl-31888067
ABSTRACT
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 µg/mL and SI of 7.1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbazoles / VIH-1 / Alcaloides / Clausena Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbazoles / VIH-1 / Alcaloides / Clausena Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China