The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective.
Cell Mol Life Sci
; 77(5): 819-833, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31893312
ABSTRACT
Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and inflammation, hallmarks of nAMD. This knowledge has propelled the development of a new group of therapeutic strategies focused on gene therapy. The present review provides an update on current gene therapies in ocular angiogenesis, particularly nAMD, from both basic and clinical perspectives.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Terapia Genética
/
Proteínas Reguladoras de la Apoptosis
/
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
/
Subunidad alfa del Factor 1 Inducible por Hipoxia
/
Degeneración Macular
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2020
Tipo del documento:
Article
País de afiliación:
Suecia