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Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
Wellaway, Christopher R; Amans, Dominique; Bamborough, Paul; Barnett, Heather; Bit, Rino A; Brown, Jack A; Carlson, Neil R; Chung, Chun-Wa; Cooper, Anthony W J; Craggs, Peter D; Davis, Robert P; Dean, Tony W; Evans, John P; Gordon, Laurie; Harada, Isobel L; Hirst, David J; Humphreys, Philip G; Jones, Katherine L; Lewis, Antonia J; Lindon, Matthew J; Lugo, Dave; Mahmood, Mahnoor; McCleary, Scott; Medeiros, Patricia; Mitchell, Darren J; O'Sullivan, Michael; Le Gall, Armelle; Patel, Vipulkumar K; Patten, Chris; Poole, Darren L; Shah, Rishi R; Smith, Jane E; Stafford, Kayleigh A J; Thomas, Pamela J; Vimal, Mythily; Wall, Ian D; Watson, Robert J; Wellaway, Natalie; Yao, Gang; Prinjha, Rab K.
Afiliación
  • Wellaway CR; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Amans D; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Bamborough P; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Barnett H; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Bit RA; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Brown JA; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Carlson NR; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States.
  • Chung CW; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Cooper AWJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Craggs PD; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Davis RP; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Dean TW; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Evans JP; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Gordon L; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Harada IL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Hirst DJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Humphreys PG; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Jones KL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Lewis AJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Lindon MJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Lugo D; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Mahmood M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • McCleary S; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Medeiros P; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States.
  • Mitchell DJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • O'Sullivan M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Le Gall A; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Patel VK; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Patten C; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Poole DL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Shah RR; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Smith JE; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Stafford KAJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Thomas PJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Vimal M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Wall ID; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Watson RJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Wellaway N; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Yao G; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States.
  • Prinjha RK; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
J Med Chem ; 63(2): 714-746, 2020 01 23.
Article en En | MEDLINE | ID: mdl-31904959
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Ensayos Analíticos de Alto Rendimiento Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Ensayos Analíticos de Alto Rendimiento Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido