Matching Static and Dynamic Compliance of Small-Diameter Arteries, with Poly(lactide-co-caprolactone) Copolymers: In Vitro and In Vivo Studies.
Macromol Biosci
; 20(3): e1900234, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-31912982
ABSTRACT
Mechanical mismatch between vascular grafts and blood vessels is a major cause of smaller diameter vascular graft failure. To minimize this mismatch, several poly-l-lactide-co-ε-caprolactone (PLC) copolymers are evaluated as candidate materials to fabricate a small diameter graft. Using these materials, tubular prostheses of 4 mm inner diameter are fabricated by dip-coating. In vitro static and dynamic compliance tests are conducted, using custom-built apparatus featuring a closed flow system with water at 37 °C. Grafts of PLC monomer ratio of 5050 are the most compliant (1.56% ± 0.31âmm Hg-2 ), close to that of porcine aortic branch arteries (1.56% ± 0.43âmm Hg-2 ), but underwent high continuous dilatation (87 µm min-1 ). Better matching is achieved by optimizing the thickness of a tubular conduit made from 7030 PLC grafts. In vivo implantation and function of a PLC 7030 conduit of 150 µm wall-thickness (WT) are tested as a rabbit aorta bypass. An implanted 150 µm WT PLC 7030 prosthesis is observed over 3 h. The recorded angiogram shows continuous blood flow, no aneurysmal dilatation, leaks, or acute thrombosis during the in vivo test, indicating the potential for clinical applications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta
/
Poliésteres
/
Ensayo de Materiales
/
Prótesis Vascular
Límite:
Animals
Idioma:
En
Revista:
Macromol Biosci
Asunto de la revista:
BIOQUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Singapur