The carbohydrate chains of influenza virus hemagglutinin.
Carbohydr Res
; 178: 165-81, 1988 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-3191507
ABSTRACT
The major surface antigen of influenza virus A/Leningrad/385/80 (H3N2), H3 hemagglutinin, as well as its heavy and light subunits were obtained by bromelain treatment, followed by gel chromatography. Carbohydrate chains were split off from both subunits by lithium borohydride-lithium hydroxide in aqueous 2-methyl-2-propanol, and individual oligosaccharides isolated. The main oligosaccharides, whose structure was determined by 1H-n.m.r. spectroscopy and chemical methods, are of the ordinary oligomannoside and complex types. It was found that, in spite of the great difference in number of glycosylation sites in heavy and light subunits, the amount and even relative abundance of variants of carbohydrate chains in both subunits are very similar.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Carbohidratos
/
Hemaglutininas Virales
/
Antígenos de Superficie
Idioma:
En
Revista:
Carbohydr Res
Año:
1988
Tipo del documento:
Article