Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.

Gupta, Suprit; Prajapati, Avi; Gulati, Mansi; Gautam, Shailendra K; Kumar, Sushil; Dalal, Vipin; Talmon, Geoffrey A; Rachagani, Satyanarayana; Jain, Maneesh

Gupta, Suprit; Prajapati, Avi; Gulati, Mansi; Gautam, Shailendra K; Kumar, Sushil; Dalal, Vipin; Talmon, Geoffrey A; Rachagani, Satyanarayana; Jain, Maneesh.

Afiliación

Gupta S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Prajapati A; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Gulati M; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Gautam SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kumar S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Dalal V; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Talmon GA; Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Rachagani S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jain M; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: mjain@unmc.edu.

Neoplasia ; 22(2): 98-110, 2020 02.

Article en En | MEDLINE | ID: mdl-31923844

Asunto(s)

Endotelina-1/genética; Inflamación/genética; Neoplasias Pancreáticas/genética; Pancreatitis/genética; Receptor de Endotelina A/genética; Receptor de Endotelina B/genética; Amilasas/genética; Animales; Ceruletida/toxicidad; Modelos Animales de Enfermedad; Enzimas Convertidoras de Endotelina/genética; Regulación de la Expresión Génica/genética; Humanos; Inflamación/inducido químicamente; Inflamación/patología; Ratones; Oncogenes/genética; Neoplasias Pancreáticas/patología; Pancreatitis/inducido químicamente; Pancreatitis/patología; Proteínas Proto-Oncogénicas p21(ras)/genética

Palabras clave

Acinar-ductal metaplasia; Endothelin; Oncogenic K-ras; PanIN lesions; Pancreatic injury; Pancreatitis; Precancerous lesions

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pancreatitis / Endotelina-1 / Receptor de Endotelina A / Receptor de Endotelina B / Inflamación Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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