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Nutrient-wide association study of 92 foods and nutrients and breast cancer risk.
Heath, Alicia K; Muller, David C; van den Brandt, Piet A; Papadimitriou, Nikos; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Weiderpass, Elisabete; Fagherazzi, Guy; Boeing, Heiner; Ferrari, Pietro; Olsen, Anja; Tjønneland, Anne; Arveux, Patrick; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; Kühn, Tilman; Turzanski-Fortner, Renée; Schulze, Matthias B; Karakatsani, Anna; Thriskos, Paschalis; Trichopoulou, Antonia; Masala, Giovanna; Contiero, Paolo; Ricceri, Fulvio; Panico, Salvatore; Bueno-de-Mesquita, Bas; Bakker, Marije F; van Gils, Carla H; Olsen, Karina Standahl; Skeie, Guri; Lasheras, Cristina; Agudo, Antonio; Rodríguez-Barranco, Miguel; Sánchez, Maria-José; Amiano, Pilar; Chirlaque, María-Dolores; Barricarte, Aurelio; Drake, Isabel; Ericson, Ulrika; Johansson, Ingegerd; Winkvist, Anna; Key, Tim; Freisling, Heinz; His, Mathilde; Huybrechts, Inge; Christakoudi, Sofia; Ellingjord-Dale, Merete; Riboli, Elio; Tsilidis, Konstantinos K.
Afiliación
  • Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK. a.heath@imperial.ac.uk.
  • Muller DC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK.
  • van den Brandt PA; Department of Epidemiology, Maastricht University Medical Centre, Maastricht, the Netherlands.
  • Papadimitriou N; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
  • Critselis E; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Gunter M; Proteomics Facility, Center for Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  • Vineis P; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
  • Weiderpass E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK.
  • Fagherazzi G; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Boeing H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK.
  • Ferrari P; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Olsen A; Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy, Villejuif, France.
  • Tjønneland A; Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.
  • Arveux P; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Boutron-Ruault MC; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Mancini FR; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Kühn T; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Turzanski-Fortner R; University of Copenhagen, Copenhagen, Denmark.
  • Schulze MB; Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy, Villejuif, France.
  • Karakatsani A; Breast and Gynaecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre, UNICANCER, Dijon, France.
  • Thriskos P; Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy, Villejuif, France.
  • Trichopoulou A; Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy, Villejuif, France.
  • Masala G; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Contiero P; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Ricceri F; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Panico S; Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany.
  • Bueno-de-Mesquita B; Hellenic Health Foundation, Athens, Greece.
  • Bakker MF; 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece.
  • van Gils CH; Hellenic Health Foundation, Athens, Greece.
  • Olsen KS; Hellenic Health Foundation, Athens, Greece.
  • Skeie G; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
  • Lasheras C; Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
  • Agudo A; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
  • Rodríguez-Barranco M; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, Italy.
  • Sánchez MJ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
  • Amiano P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK.
  • Chirlaque MD; Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
  • Barricarte A; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
  • Drake I; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia.
  • Ericson U; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Johansson I; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Winkvist A; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Key T; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Freisling H; Functional Biology Department, School of Medicine, University of Oviedo, Asturias, Spain.
  • His M; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology - ICO, Group of Research on Nutrition and Cancer, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet of Llobregat, Barcelona, Spain.
  • Huybrechts I; Andalusian School of Public Health (EASP), Granada, Spain.
  • Christakoudi S; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
  • Ellingjord-Dale M; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Riboli E; Universidad de Granada (UGR), Granada, Spain.
  • Tsilidis KK; Andalusian School of Public Health (EASP), Granada, Spain.
Breast Cancer Res ; 22(1): 5, 2020 01 13.
Article en En | MEDLINE | ID: mdl-31931881
BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Fibras de la Dieta / Nutrientes / Encuestas y Cuestionarios / Dieta / Conducta Alimentaria Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Fibras de la Dieta / Nutrientes / Encuestas y Cuestionarios / Dieta / Conducta Alimentaria Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido