Fabrication of Collagen Films with Enhanced Mechanical and Enzymatic Stability through Thermal Treatment in Fluorous Media.
ACS Appl Mater Interfaces
; 12(5): 6590-6597, 2020 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-31935058
ABSTRACT
Collagen I (Col-I) is widely used in the fabrication of biomaterials due to its biocompatibility; however, Col-I based biomaterials are susceptible to mechanical failure during handling, which limits their applicability to biomaterials. Chemical or physical treatment can improve the mechanical properties of collagen; however, these processes can create issues of cytotoxicity or denaturation. We report here an alternative strategy to improve the stability and mechanical properties of Col-I while preserving its native structure, through thermal treatment in fluorous media. Thermal treatment of Col-I in fluorous solvent generates compact, stable films with significantly increased mechanical strength. Furthermore, the use of fluorous media significantly reduces the extent of swelling and the rate of proteolytic degradation, but it preserves the high cell biocompatibility.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Compuestos de Flúor
/
Colágeno Tipo I
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Asunto de la revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos