Phylogenetic Analyses of Chemokine Receptors from Sequence Retrieval to Phylogenetic Trees.
Methods Mol Biol
; 2108: 313-343, 2020.
Article
en En
| MEDLINE
| ID: mdl-31939192
ABSTRACT
Phylogenetic trees are an essential requisite for comparative biology studies where hypotheses regarding the evolution of genes can be investigated. Trees provide visual and statistical guides to characterize the degree of relatedness among biological entities from genes to species. In a tree, ancestor-descendant relationships are represented by connections, and closely related entities share most of these links. In this chapter, I outlined a method to retrieve and label amino acid and nucleotide sequences of chemokine receptors, align them in sequence matrices, determine their best-model of molecular evolution, and estimate the corresponding phylogenetic trees with distance and maximum likelihood approaches. Most of these analyses are performed within the R environment, and all of these methods use open-source software.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Filogenia
/
Biología Computacional
/
Receptores de Quimiocina
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos