Clinical Use of κ Free Light Chains Index as a Screening Test for Multiple Sclerosis.
Lab Med
; 51(4): 402-407, 2020 Jul 08.
Article
en En
| MEDLINE
| ID: mdl-31943078
ABSTRACT
OBJECTIVE:
To assess the usefulness of the κ free light chain index (κFLCi) as a screening test to identify patients with suspected MS.METHODS:
The study included 56 patients with a request to test for oligoclonal bands (OCBs). OCBs were detected by isoelectric focusing, followed by immunofixation. Cerebrospinal fluid (CSF) and serum κFLC were measured by a turbidimetric assay. Also, the κFLC index (κFLCi) was calculated.RESULTS:
CSF κFLC levels and κFLCi were significantly higher in patients with multiple sclerosis (MS) than in patients with other neurological diseases (NDs; P < .001 and P < .001, respectively). At the cutoff value of 2.9, the κFLCi detected MS with sensitivity of 97% and specificity of 65%. Overall, 92% patients with κFLCi of 2.9 or greater and who had tested positive for OCBs were diagnosed as having MS.CONCLUSION:
Our findings support the use of κFLCi as a screening test when MS is suspected, followed by OCB detection as a confirmatory test for the diagnosis of MS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cadenas Ligeras de Inmunoglobulina
/
Esclerosis Múltiple
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Lab Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia