When Cold Is Hot: Immune Checkpoint Inhibition Therapy for Rhabdoid Tumors.
Cancer Cell
; 36(6): 575-576, 2019 Dec 09.
Article
en En
| MEDLINE
| ID: mdl-31951557
ABSTRACT
Carcinogen-induced cancers typically have high mutation burdens and an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (ICIs). However, cancers with loss-of-function mutations in the SWI/SNF complex have few additional mutations yet also have an inflamed immunophenotype and should respond to ICI therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Tumor Rabdoide
/
Ensamble y Desensamble de Cromatina
/
Inmunoterapia
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Cancer Cell
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos