Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop.

Gay, Lauren; Renne, Rolf

Gay, Lauren; Renne, Rolf.

Afiliación

Gay L; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA.
Renne R; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA; University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA; University of Florida Genetics Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: rrenne@ufl.edu.

Cell Host Microbe ; 27(1): 8-10, 2020 01 08.

Article en En | MEDLINE | ID: mdl-31951824

RESUMEN

In this issue of Cell Host & Microbe, Hancock et al., 2020 show that latent HCMV infection, and specifically miR-US5-2, induces TGF-ß secretion, which inhibits myelopoiesis in uninfected HPCs. They also show that HCMV-infected cells become resistant to TGF-ß signaling through targeting of SMAD3 by miR-UL22-A-3p and -5p.

Asunto(s)

Citomegalovirus/genética; MicroARNs; Células Madre Hematopoyéticas; Humanos; Factor de Crecimiento Transformador beta; Latencia del Virus

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citomegalovirus / MicroARNs Límite: Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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