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IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function.
St Paul, Michael; Saibil, Samuel D; Lien, Scott C; Han, SeongJun; Sayad, Azin; Mulder, David T; Garcia-Batres, Carlos R; Elford, Alisha R; Israni-Winger, Kavita; Robert-Tissot, Céline; Zon, Michael; Katz, Sarah Rachel; Shaw, Patricia A; Clarke, Blaise A; Bernardini, Marcus Q; Nguyen, Linh T; Haibe-Kains, Benjamin; Pugh, Trevor J; Ohashi, Pamela S.
Afiliación
  • St Paul M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Saibil SD; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Lien SC; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Han S; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Sayad A; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Mulder DT; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Garcia-Batres CR; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Elford AR; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Israni-Winger K; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Robert-Tissot C; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Zon M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Katz SR; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Shaw PA; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Clarke BA; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Bernardini MQ; Division of Gynecologic Oncology, University Health Network, Toronto, Ontario, Canada.
  • Nguyen LT; Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Haibe-Kains B; Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Pugh TJ; Division of Gynecologic Oncology, University Health Network, Toronto, Ontario, Canada.
  • Ohashi PS; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
Cancer Immunol Res ; 8(3): 321-333, 2020 03.
Article en En | MEDLINE | ID: mdl-31964625
CD8+ T cells can be polarized into several different subsets as defined by the cytokines they produce and the transcription factors that govern their differentiation. Here, we identified the polarizing conditions to induce an IL22-producing CD8+ Tc22 subset, which is dependent on IL6 and the aryl hydrocarbon receptor transcription factor. Further characterization showed that this subset was highly cytolytic and expressed a distinct cytokine profile and transcriptome relative to other subsets. In addition, polarized Tc22 were able to control tumor growth as well as, if not better than, the traditional IFNγ-producing Tc1 subset. Tc22s were also found to infiltrate the tumors of human patients with ovarian cancer, comprising up to approximately 30% of expanded CD8+ tumor-infiltrating lymphocytes (TIL). Importantly, IL22 production in these CD8+ TILs correlated with improved recurrence-free survival. Given the antitumor properties of Tc22 cells, it may be prudent to polarize T cells to the Tc22 lineage when using chimeric antigen receptor (CAR)-T or T-cell receptor (TCR) transduction-based immunotherapies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Linfocitos T Citotóxicos / Inmunoterapia Adoptiva / Subgrupos de Linfocitos T / Linfocitos Infiltrantes de Tumor / Interleucinas / Interleucina-6 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Immunol Res Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Linfocitos T Citotóxicos / Inmunoterapia Adoptiva / Subgrupos de Linfocitos T / Linfocitos Infiltrantes de Tumor / Interleucinas / Interleucina-6 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Immunol Res Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos