Significant association between methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: A meta-analysis update.
Medicine (Baltimore)
; 99(4): e18720, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31977861
ABSTRACT
The methylenetetrahydrofolate reductase (MTHFR) may play a pathological role in polycystic ovary syndrome (PCOS). However, the conclusions of published reports on the relationship between the MTHFR C677T polymorphism and PCOS risk remain controversial.To derive a more precise estimation we performed a metaanalysis based on 22 studies that together included 2405 cases and 2419 controls. PubMed, EMBASE, WanFang and the Chinese National Knowledge Infrastructure databases were used to retrieve articles up to up to October 28, 2019. The crude odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated to evaluate the association.Metaanalysis results showed a significant association between the MTHFR C677T polymorphism and PCOS risk in 3 genetic models (allele model ORâ=â1.40, 95% CIâ=â1.27-1.53; dominant model ORâ=â1.47, 95% CIâ=â1.17-1.85); homozygous model ORâ=â1.90, 95% CIâ=â1.55-2.32). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology, and genotype methods.This metaanalysis suggests that the T-allele of the MTHFR C677T polymorphism is associated with an increased risk of PCOS, especially in Asians further studies with larger population sizes are needed to confirm these results.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
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Metilenotetrahidrofolato Reductasa (NADPH2)
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Female
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Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2020
Tipo del documento:
Article