Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms.
J Neuroimmunol
; 340: 577163, 2020 03 15.
Article
en En
| MEDLINE
| ID: mdl-31982706
ABSTRACT
In multiple sclerosis (MS), cognitive dysfunction is common but difficult to treat. We analyzed the impact of dimethyl fumarate, an MS drug with neuroprotective properties, in spatial memory performance in a mouse model of MS and looked for structural correlates in the hippocampus. Treated mice presented better cognitive performance which was not associated with structural hippocampal damage but with decreased demyelination in the fimbria. Dimethyl fumarate, even if initiated after hindlimb paralysis, ameliorated memory deficits in the MS mouse model due, at least in part, to its positive impact in the demyelination of the main hippocampal output pathway.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cognición
/
Fármacos Neuroprotectores
/
Encefalomielitis Autoinmune Experimental
/
Dimetilfumarato
/
Hipocampo
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Portugal