Kinesthetic cortical area anterior to primary somatic sensory cortex in the raccoon (Procyon lotor).

ABSTRACT

Extracellular microelectrode recording of cortical unit activity, with subsequent histological examination, was used to determine the extent, organization, and cytoarchitecture of the zone of muscle afferent projections (kinesthetic cortex) anterior to the primary somatic sensory cortex in anesthetized raccoons. Activity was evoked in response to mechanical stimulation of muscles from which the overlying skin had been dissected away. Most kinesthetic responses were elicited in a contiguous cortical area, which included the anterior bank of the lateral arm, and the fundus and posterior bank of the medial arm of the medial central sulcus; and the anterior two-thirds of the interfundic rise within the interbrachial sulcus. Some responses were recorded in a separate small area of the anterior bank at the medial end of the lateral central sulcus. Somatotopy was evident with forelimb represented lateral to hindlimb. Proximal limb muscles were represented in the center of the medial central sulcus; distal muscle projections were medial (hindlimb) or lateral (forelimb) in the same sulcus. Most representations were of flexor and extensor muscles of the contralateral carpus and forepaw digits. Activity at a given recording locus in the kinesthetic area could be elicited by both flexor and extensor muscles, which acted about a common joint. Low amplitude units evoked by cutaneous stimulation of the dissected skin were recorded in the kinesthetic area; these were from receptive fields of skin that normally overlay the muscles whose higher-amplitude evoked kinesthetic units were represented in that same recording locus. The kinesthetic zone was anterior to primary somatic sensory cortex, where the outer stripe of Baillarger and granular layer IV become attenuated. In the hindlimb muscle representation area, the additional criterion of area 3a (large pyramidal cells in layer V) was seen. However, no cytoarchitecture could be identified that was consistently associated with the kinesthetic cortex.