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The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability.
Gottwald, Esther M; Schuh, Claus D; Drücker, Patrick; Haenni, Dominik; Pearson, Adam; Ghazi, Susan; Bugarski, Milica; Polesel, Marcello; Duss, Michael; Landau, Ehud M; Kaech, Andres; Ziegler, Urs; Lundby, Anne K M; Lundby, Carsten; Dittrich, Petra S; Hall, Andrew M.
Afiliación
  • Gottwald EM; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Schuh CD; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Drücker P; Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland.
  • Haenni D; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Pearson A; Center for Microscopy and Image Analysis, University of Zurich, Zurich, Switzerland.
  • Ghazi S; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Bugarski M; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Polesel M; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Duss M; Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Landau EM; Department of Chemistry, University of Zurich, Zurich, Switzerland.
  • Kaech A; Department of Chemistry, University of Zurich, Zurich, Switzerland.
  • Ziegler U; Center for Microscopy and Image Analysis, University of Zurich, Zurich, Switzerland.
  • Lundby AKM; Center for Microscopy and Image Analysis, University of Zurich, Zurich, Switzerland.
  • Lundby C; Institute of Physiology, University of Zurich, Zurich, Switzerland.
  • Dittrich PS; Institute of Physiology, University of Zurich, Zurich, Switzerland.
  • Hall AM; Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland.
Sci Rep ; 10(1): 1577, 2020 01 31.
Article en En | MEDLINE | ID: mdl-32005861
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quelantes del Hierro / Membranas Mitocondriales / Potencial de la Membrana Mitocondrial / Deferasirox / Mitocondrias Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quelantes del Hierro / Membranas Mitocondriales / Potencial de la Membrana Mitocondrial / Deferasirox / Mitocondrias Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido