Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.

Xiong, Gaofeng; Chen, Jie; Zhang, Guoying; Wang, Shike; Kawasaki, Kunito; Zhu, Jieqing; Zhang, Yan; Nagata, Kazuhiro; Li, Zhenyu; Zhou, Binhua P; Xu, Ren

Xiong, Gaofeng; Chen, Jie; Zhang, Guoying; Wang, Shike; Kawasaki, Kunito; Zhu, Jieqing; Zhang, Yan; Nagata, Kazuhiro; Li, Zhenyu; Zhou, Binhua P; Xu, Ren.

Afiliación

Xiong G; Markey Cancer Center, University of Kentucky, Lexington, KY 40536.
Chen J; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.
Zhang G; Markey Cancer Center, University of Kentucky, Lexington, KY 40536.
Wang S; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.
Kawasaki K; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536.
Zhu J; Markey Cancer Center, University of Kentucky, Lexington, KY 40536.
Zhang Y; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.
Nagata K; Department of Molecular and Cellular Biology, Kyoto Sangyo University, Kyoto 603-8555, Japan.
Li Z; Markey Cancer Center, University of Kentucky, Lexington, KY 40536.
Zhou BP; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.
Xu R; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536.

Proc Natl Acad Sci U S A ; 117(7): 3748-3758, 2020 02 18.

Article en En | MEDLINE | ID: mdl-32015106

Asunto(s)

Plaquetas/metabolismo; Neoplasias de la Mama/metabolismo; Colágeno/metabolismo; Proteínas del Choque Térmico HSP47/metabolismo; Células Neoplásicas Circulantes/metabolismo; Animales; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Neoplasias de la Mama/fisiopatología; Transición Epitelial-Mesenquimal; Matriz Extracelular/genética; Matriz Extracelular/metabolismo; Femenino; Amplificación de Genes; Proteínas del Choque Térmico HSP47/genética; Humanos; Ratones SCID; Metástasis de la Neoplasia

Palabras clave

breast cancer; cancer metastasis; circulating tumor cell; epithelial-mesenchymal transition; extracellular matrix

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Neoplasias de la Mama / Colágeno / Proteínas del Choque Térmico HSP47 / Células Neoplásicas Circulantes Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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