Multigene mutational profiling of biliary tract cancer is related to the pattern of recurrence in surgically resected patients.
Updates Surg
; 72(1): 119-128, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-32020551
ABSTRACT
The aim of the present study was to investigate the relationship between the mutational gene profile and recurrence in biliary tract cancers (BTC). A total of 103 specimens of patients with BTC, who underwent curative surgery in a single tertiary HPB surgery referral center from 1990 to 2012, were assessed for mutational status in 52 cancer-related genes. Considering the different types of BTC, the 5-year recurrence-free survival (RFS) rate was 16.7% (median RFS 7 months) in gallbladder cancer, 42.9% (median RFS 26.4 months) in intrahepatic cholangiocarcinoma, and 19.7% (median RFS 16.5 months) in perihilar cholangiocarcinoma, p = 0.166. At the multivariate analysis including clinical, pathological, and molecular features, the factors independently related to RFS were radicality of surgery (OR 2.050, CI 1.104-3.807, p = 0.023), LN status (OR 1.835, CI 1.006-3.348, p = 0.048), mutational status of ARID1A (OR 2.566, CI 1.174-5.608, p = 0.018), and TP53 (OR 2.805, CI 4.432-5.496, p = 0.003). ARID1A mutation was associated with a local and systemic recurrence in the 43% and 29% of cases, respectively; and TP53 mutation was associated with a local and systemic recurrence in the 29% and 41% of cases. Moreover, TP53 was most commonly mutated in tumor of patients with early recurrence, p = 0.044. ARID1A and TP53 mutations seem to be related to poor outcome after surgery and may be considered molecular predictors of the biological aggressiveness in BTC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Neoplasias del Sistema Biliar
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Proteína p53 Supresora de Tumor
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Proteínas de Unión al ADN
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Genes Relacionados con las Neoplasias
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Estudios de Asociación Genética
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Mutación
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Recurrencia Local de Neoplasia
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Updates Surg
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia