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The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old.
Elshorbagy, Hatem Hamed; Barseem, Naglaa Fathy; Suliman, Hany Abdelaziz; Talaat, Eman; AlSHOKARY, Ashraf Hamed; Abdelghani, Waleed Elsayed; Abdulsamea, Sameh Elsayed; Maksoud, Yehia Hamed Abdel; Azab, Sanaa Mohammed; Elsadek, Akram Elshafey; Nour El Din, Dalia Mohamed.
Afiliación
  • Elshorbagy HH; Pediatric department, Menofia University, Minufya, Egypt.
  • Barseem NF; Pediatric department, Menofia University, Minufya, Egypt.
  • Suliman HA; Pediatric department, Benha University, Minufya, Egypt.
  • Talaat E; Ain shams University, Pediatric department, Cairo, Egypt.
  • AlSHOKARY AH; Pediatric department, Benha University, Minufya, Egypt.
  • Abdelghani WE; Pediatric department, Benha University, Minufya, Egypt.
  • Abdulsamea SE; Pediatric department, Benha University, Minufya, Egypt.
  • Maksoud YHA; Pediatric department, Benha University, Minufya, Egypt.
  • Azab SM; Department of Pediatric, Faculty of Medicine, Al-azhar University, Cairo, Egypt.
  • Elsadek AE; Pediatric department, Benha University, Minufya, Egypt.
  • Nour El Din DM; Clinical pathology-department, Benha University, Minufya, Egypt.
Iran J Child Neurol ; 14(1): 31-41, 2020.
Article en En | MEDLINE | ID: mdl-32021626
ABSTRACT

OBJECTIVES:

To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS &

METHODS:

A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40 children with epilepsy on traditional AEDs, and group 2 included 40 children with epilepsy on newer AEDs. Forty healthy children were also included as the control group (group 3). We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH).

RESULTS:

In epileptic children treated with traditional drugs, there was a significant reduction in the serum level of FT4 and a significant increase in TSH concentration, compared to the control group (P<0.001). Conversely, epileptic children treated with newer AEDs showed no significant changes in the serum concentrations of FT3, FT4, and TSH, compared to the control group.

CONCLUSION:

Traditional AEDs have more significant effects on thyroid hormone profile, compared to newer AEDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Child Neurol Año: 2020 Tipo del documento: Article País de afiliación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Child Neurol Año: 2020 Tipo del documento: Article País de afiliación: Egipto