Disulfiram as a potent metallo-ß-lactamase inhibitor with dual functional mechanisms.
Chem Commun (Camb)
; 56(18): 2755-2758, 2020 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-32022035
ABSTRACT
We report a promising NDM-1 inhibitor, disulfiram, which can covalently bind to NDM-1 by forming an S-S bond with the Cys208 residue. Its copper-containing metabolite in vivo, Cu(DTC)2, also inactivated NDM-1 through oxidizing the Zn(ii) thiolate site of the enzyme, therefore exhibiting dual functional inhibitory potential against B1 and B2 subclass MßLs.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Escherichia coli
/
Disulfiram
/
Inhibidores de beta-Lactamasas
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article