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A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1α.
Wang, Xuelei; Chen, Xiaofang; Zhang, Xiumin; Su, Chunyan; Yang, Mengxia; He, Wei; Du, Yu; Si, Shuyi; Wang, Li; Hong, Bin.
Afiliación
  • Wang X; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Chen X; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Zhang X; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Su C; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Yang M; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China; CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnol
  • He W; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China; CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnol
  • Du Y; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Si S; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China.
  • Wang L; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China. Electronic address: wangli@imb.pumc.edu.cn.
  • Hong B; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Tiantan xili, Beijing 100050, China; CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnol
EBioMedicine ; 52: 102650, 2020 Feb.
Article en En | MEDLINE | ID: mdl-32058941
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Regulación de la Expresión Génica / Aterosclerosis / Proproteína Convertasa 9 / Proteína Forkhead Box O3 / Proteína Forkhead Box O1 / Inhibidores de PCSK9 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: EBioMedicine Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Regulación de la Expresión Génica / Aterosclerosis / Proproteína Convertasa 9 / Proteína Forkhead Box O3 / Proteína Forkhead Box O1 / Inhibidores de PCSK9 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: EBioMedicine Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos