Exploring the Potential Feasibility of Intra-Articular Adeno-Associated Virus-Mediated Gene Therapy for Hemophilia Arthropathy.

Zhang, Feixu; Yan, Xiaobo; Li, Min; Hua, Baolai; Xiao, Xiao; Monahan, Paul E; Sun, Junjiang

Zhang, Feixu; Yan, Xiaobo; Li, Min; Hua, Baolai; Xiao, Xiao; Monahan, Paul E; Sun, Junjiang.

Afiliación

Zhang F; School of Bioengineering, East China University of Science and Technology, Shanghai, China.
Yan X; School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Li M; Department of Hematology, Clinical Medical College, Yangzhou University, Yangzhou, China.
Hua B; School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Xiao X; Department of Hematology, Clinical Medical College, Yangzhou University, Yangzhou, China.
Monahan PE; School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Sun J; Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina.

Hum Gene Ther ; 31(7-8): 448-458, 2020 04.

Article en En | MEDLINE | ID: mdl-32079420

Asunto(s)

Dependovirus; Factor VIII/genética; Factor VIII/uso terapéutico; Terapia Genética/métodos; Hemartrosis/terapia; Hemofilia A/terapia; Animales; Estudios de Factibilidad; Humanos; Ratones; Ratones Noqueados; Proteínas Recombinantes/uso terapéutico; Sinovitis/terapia

Palabras clave

adeno-associated virus; arthropathy; hemophilia; intraarticular; neutralizing antibody; recombinant human factor VIII

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor VIII / Terapia Genética / Dependovirus / Hemartrosis / Hemofilia A Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Hum Gene Ther Asunto de la revista: GENETICA MEDICA / TERAPEUTICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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