Cord Blood Banking and Transplantation in a National Program: Thirteen Years of Experience.
Arch Med Res
; 51(1): 54-62, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-32086109
ABSTRACT
BACKGROUND:
The umbilical cord blood bank at the Mexican Institute of Social Security (IMSS-CBB) was established in January 2005. This lead to the development of the UCB transplantation program. Herein, we describe the experience generated during these 13 years. STUDY DESIGN ANDMETHODS:
Donor selection, as well as UCB collection, processing, and banking were performed under good manufacturing practices and standard operating procedures. UCB units were thawed, processed, and released for transplantation based on HLA and nucleated cell content.RESULTS:
From January 2005-December 2017, 1,298 UCB units were banked; 164 of them were released for transplantation, and 118 UCB transplants were performed. Ninety-four transplants were performed in pediatric patients and 24 in adults. Sixty percent of them corresponded to patients with leukemia, 19% were patients with marrow failure, and the rest had immunodeficiency, hemoglobinopathy, metabolic disorders, or solid tumors. Engraftment was observed in 67 patients (57% of transplanted patients) and 64% of them were still alive when writing this article. In contrast, only 13 of the 51 (25%) non-engrafting patients were alive. At the time of writing this article, the disease-free survival rate was 37%, and the overall survival rate was 47%, with survival periods of 161-3,721 days.CONCLUSION:
The IMSS UCB banking and transplantation program has had a significant impact for many IMSS patients. The hematopoietic transplantation program at our institution has benefited from the use of UCB as a source of transplantable cells.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bancos de Sangre
/
Trasplante de Células Madre de Sangre del Cordón Umbilical
/
Sangre Fetal
/
Almacenamiento de Sangre
/
Programas Nacionales de Salud
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Arch Med Res
Asunto de la revista:
MEDICINA
Año:
2020
Tipo del documento:
Article