Targeting apoptotic caspases in cancer.
Biochim Biophys Acta Mol Cell Res
; 1867(6): 118688, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32087180
ABSTRACT
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis. Many conventional cancer therapies induce apoptosis to remove the cancer cell by engaging these caspases indirectly. Newer therapeutic applications have been designed, including those that specifically activate individual caspases using gene therapy approaches and small molecules that repress natural inhibitors of caspases already present in the cell. For such approaches to have maximal clinical efficacy, emerging insights into non-apoptotic roles of these caspases need to be considered. This review will discuss the roles of caspases as safeguards against cancer in the context of the advantages and potential limitations of targeting apoptotic caspases for the treatment of cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Caspasas
/
Neoplasias
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Mol Cell Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos