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Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis.
Knowles, Sonja L; Raja, Huzefa A; Isawi, Israa H; Flores-Bocanegra, Laura; Reggio, Patricia H; Pearce, Cedric J; Burdette, Joanna E; Rokas, Antonis; Oberlies, Nicholas H.
Afiliación
  • Knowles SL; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Raja HA; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Isawi IH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Flores-Bocanegra L; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Reggio PH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Pearce CJ; Mycosynthetix, Inc., Hillsborough, North Carolina 27278, United States.
  • Burdette JE; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Rokas A; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, United States.
  • Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Org Lett ; 22(5): 1878-1882, 2020 03 06.
Article en En | MEDLINE | ID: mdl-32096649
Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, and melanoma cancer cell lines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ascomicetos / Aspergillus / Xylariales / Antineoplásicos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ascomicetos / Aspergillus / Xylariales / Antineoplásicos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos