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Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates.
Maza, Johnathan C; Ramsey, Alexandra V; Mehare, Meire; Krska, Shane W; Parish, Craig A; Francis, Matthew B.
Afiliación
  • Maza JC; Department of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.
  • Ramsey AV; Department of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.
  • Mehare M; Department of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.
  • Krska SW; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA.
  • Parish CA; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA.
  • Francis MB; Department of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu and Materials Science Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA.
Org Biomol Chem ; 18(10): 1881-1885, 2020 03 14.
Article en En | MEDLINE | ID: mdl-32100807
ABSTRACT
A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolina / Proteínas / Aminas / Hidrazinas Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolina / Proteínas / Aminas / Hidrazinas Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos