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Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.
Gao, Xiaofei; Zhang, Zhaohuan; Mashimo, Tomoyuki; Shen, Bo; Nyagilo, James; Wang, Hao; Wang, Yihui; Liu, Zhida; Mulgaonkar, Aditi; Hu, Xiao-Ling; Piccirillo, Sara G M; Eskiocak, Ugur; Davé, Digant P; Qin, Song; Yang, Yongjie; Sun, Xiankai; Fu, Yang-Xin; Zong, Hui; Sun, Wenzhi; Bachoo, Robert M; Ge, Woo-Ping.
Afiliación
  • Gao X; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Zhang Z; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
  • Mashimo T; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Shen B; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Nyagilo J; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang H; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang Y; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 4300030, China.
  • Liu Z; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Mulgaonkar A; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Hu XL; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Piccirillo SGM; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Eskiocak U; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Davé DP; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Bioengineering, University of Texas, Arlington, TX 76010, USA.
  • Qin S; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Yang Y; Department of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Tufts University, Boston, MA 02111, USA.
  • Sun X; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Fu YX; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Zong H; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
  • Sun W; Chinese Institute for Brain Research, Beijing 102206, China; School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
  • Bachoo RM; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwest
  • Ge WP; Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center
Cell Rep ; 30(8): 2489-2500.e5, 2020 02 25.
Article en En | MEDLINE | ID: mdl-32101730
ABSTRACT
Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that individual gliomas communicate with distinct sets of non-glioma cells, including glial cells, neurons, and vascular cells. Transfer of genetic material is achieved mainly through extracellular vesicles (EVs), although cell fusion also plays a minor role. We further demonstrate that EV-mediated communication leads to the increase of synaptic activity in neurons. Blocking EV release causes a reduction of glioma growth in vivo. Our findings indicate that EV-mediated interaction between glioma cells and non-glioma brain cells alters the tumor microenvironment and contributes to glioma development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Comunicación Celular / Vesículas Extracelulares / Glioma Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Comunicación Celular / Vesículas Extracelulares / Glioma Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos