Plasma Endotoxin Levels Are Not Increased in Schistosoma mansoni-Infected Women without Signs or Symptoms of Hepatosplenic Disease.
Am J Trop Med Hyg
; 102(6): 1382-1385, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32124718
ABSTRACT
Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by Schistosoma mansoni have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with S. mansoni but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized Limulus amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an S. mansoni-endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with (n = 22) and without (n = 31) infection (1.001 versus 0.949 EU/mL, P = 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL, P = 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in S. mansoni infection introduce bacterial sources of endotoxin to the circulation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Bazo
/
Esquistosomiasis mansoni
/
Endotoxinas
/
Parasitosis Intestinales
/
Hepatopatías
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Animals
/
Female
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Humans
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido