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Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors.
Rowntree, Louise C; van den Heuvel, Heleen; Sun, Jessica; D'Orsogna, Lloyd J; Nguyen, Thi H O; Claas, Frans H J; Rossjohn, Jamie; Kotsimbos, Tom C; Purcell, Anthony W; Mifsud, Nicole A.
Afiliación
  • Rowntree LC; Respiratory Medicine Laboratory, Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  • van den Heuvel H; Department of Allergy, Immunology, and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia.
  • Sun J; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • D'Orsogna LJ; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Nguyen THO; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
  • Claas FHJ; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Rossjohn J; Department of Clinical Immunology and Pathwest, Fiona Stanley Hospital, Perth, WA, Australia.
  • Kotsimbos TC; School of Medicine, University of Western Australia, Perth, WA, Australia.
  • Purcell AW; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Mifsud NA; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Front Immunol ; 11: 248, 2020.
Article en En | MEDLINE | ID: mdl-32140156
T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8+ T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward HLA-B27 allotypes in a highly focused and hierarchical manner. Given the commonality of cross-reactive T cells and their potential contribution to adverse outcomes in allogeneic transplants, our study demonstrates that multiple antiviral T cells recognizing the same HLA allomorph could pose an extra layer of complexity for organ matching.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Virosis / Receptores de Antígenos de Linfocitos T / Antígeno HLA-B27 / Linfocitos T CD8-positivos / Rechazo de Injerto / Isoantígenos Límite: Humans Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Virosis / Receptores de Antígenos de Linfocitos T / Antígeno HLA-B27 / Linfocitos T CD8-positivos / Rechazo de Injerto / Isoantígenos Límite: Humans Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza