Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models.
Future Sci OA
; 6(3): FSOA442, 2020 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-32140251
ABSTRACT
AIM:
According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS &METHODS:
We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS &CONCLUSION:
Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Future Sci OA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Argentina