Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.
JACC Basic Transl Sci
; 5(2): 109-122, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-32140620
ABSTRACT
Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention.
EF, ejection fraction; LA EF, left atrial emptying fraction; LA, left atrial; LV, left ventricle; MR, mitral regurgitation; MV, mitral valve; RA, right atrial; TEM, transmission electron microscopy; TGF, transforming growth factor; chymase; fibrosis; left atrium; left ventricle; mitral regurgitation; mitral valve
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
JACC Basic Transl Sci
Año:
2020
Tipo del documento:
Article