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Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health.
Jones, Laura M; Chen, Yannic; van Oosten-Hawle, Patricija.
Afiliación
  • Jones LM; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
  • Chen Y; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
  • van Oosten-Hawle P; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Biol Chem ; 401(9): 1005-1018, 2020 08 27.
Article en En | MEDLINE | ID: mdl-32142470
Eukaryotic organisms have evolved complex and robust cellular stress response pathways to ensure maintenance of proteostasis and survival during fluctuating environmental conditions. Highly conserved stress response pathways can be triggered and coordinated at the cell-autonomous and cell-nonautonomous level by proteostasis transcription factors, including HSF1, SKN-1/NRF2, HIF1, and DAF-16/FOXO that combat proteotoxic stress caused by environmental challenges. While these transcription factors are often associated with a specific stress condition, they also direct "noncanonical" transcriptional programs that serve to integrate a multitude of physiological responses required for development, metabolism, and defense responses to pathogen infections. In this review, we outline the established function of these key proteostasis transcription factors at the cell-autonomous and cell-nonautonomous level and discuss a newly emerging stress responsive transcription factor, PQM-1, within the proteostasis network. We look beyond the canonical stress response roles of proteostasis transcription factors and highlight their function in integrating different physiological stimuli to maintain cytosolic organismal proteostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Factores de Transcripción / Salud / Proteostasis / Metabolismo Límite: Humans Idioma: En Revista: Biol Chem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Factores de Transcripción / Salud / Proteostasis / Metabolismo Límite: Humans Idioma: En Revista: Biol Chem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Alemania