CCR5 and CXCL12 allelic variants: Possible association with childhood neuroblastoma susceptibility?

ABSTRACT

Neuroblastoma (NB) is a heterogeneous and particularly malignant childhood neoplasm in its higher stages, prone to form metastasis in selected organs and for which there is still no efficient treatment available beyond surgery. Evidence indicates that chemokines and their receptors present involvement as mediators of neuroinflammation and have a neurophysiological role. In the present study, we aimed to verify if CCR5 (rs333) and CXCL12 (rs1801157) allelic variants were associated with NB. For CCR5 (rs333) D32 carriers (OR 5.96, IC 2.21-16.06) and for CXCL12 genotype 3'A/3'A (OR26.18, IC6.15-111.4) there were statistically significant differences as well to allelic frequency (OR4.20, IC 2.19-8.03). Although no correlation was verified regarding prognostic parameters for both CCR5 and CXCL12 polymorphic variants, these polymorphisms may be associated with NB susceptibility which deserve attention for future investigations.