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DIY: Visualizing the immune landscape of tumors using transcriptome and methylome data.
Gameiro, Steven F; Ghasemi, Farhad; Barrett, John W; Koropatnick, James; Nichols, Anthony C; Mymryk, Joe S; Maleki Vareki, Saman.
Afiliación
  • Gameiro SF; Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada.
  • Ghasemi F; Department of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON, Canada.
  • Barrett JW; Department of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON, Canada.
  • Koropatnick J; Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada; Department of Oncology, The University of Western Ontario, London, ON, Canada; Department of Pathology, The University of Western Ontario, London, ON, Canada; Department of Physiology and Pharmacology,
  • Nichols AC; Department of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON, Canada; Department of Oncology, The University of Western Ontario, London, ON, Canada; London Regional Cancer Program, Lawson Health Research Institute, London, ON, Canada.
  • Mymryk JS; Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada; Department of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON, Canada; Department of Oncology, The University of Western Ontario, London, ON, Canada; London Region
  • Maleki Vareki S; Department of Oncology, The University of Western Ontario, London, ON, Canada; London Regional Cancer Program, Lawson Health Research Institute, London, ON, Canada. Electronic address: saman.malekivareki@lhsc.on.ca.
Methods Enzymol ; 636: 49-76, 2020.
Article en En | MEDLINE | ID: mdl-32178827
ABSTRACT
The importance of the immune system in combating many different types of malignancies has been firmly established. Indeed, the success of immune checkpoint-blocking antibodies in cancer treatment has focused the attention of many researchers on the tumor immune microenvironment. As one consequence, the analysis of the number, type, and activation status of tumor-infiltrating leukocytes (TILs) has become an area of great interest. Detailed knowledge of the immunological profile of a given tumor has the potential to predict patient response to therapy and overall survival. This chapter is intended to summarize the steps necessary for basic comparative analysis of the infiltration and activation status of immune cells in various human solid tumors, using freely available data obtained from The Cancer Genome Atlas (TCGA).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transcriptoma / Neoplasias Límite: Humans Idioma: En Revista: Methods Enzymol Año: 2020 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transcriptoma / Neoplasias Límite: Humans Idioma: En Revista: Methods Enzymol Año: 2020 Tipo del documento: Article País de afiliación: Canadá