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Redox Activity and Nano-Bio Interactions Determine the Skin Injury Potential of Co3O4-Based Metal Oxide Nanoparticles toward Zebrafish.
Peng, Guotao; He, Yuan; Wang, Xiaoxiao; Cheng, Yan; Zhang, Haiyuan; Savolainen, Kai; Mädler, Lutz; Pokhrel, Suman; Lin, Sijie.
Afiliación
  • Peng G; College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Tongji University, Shanghai 200092, China.
  • He Y; Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
  • Wang X; College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Tongji University, Shanghai 200092, China.
  • Cheng Y; Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
  • Zhang H; College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Tongji University, Shanghai 200092, China.
  • Savolainen K; Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
  • Mädler L; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
  • Pokhrel S; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
  • Lin S; Finnish Institute of Occupational Health, Helsinki 00250, Finland.
ACS Nano ; 14(4): 4166-4177, 2020 04 28.
Article en En | MEDLINE | ID: mdl-32191835
ABSTRACT
Redox-active metal oxide nanoparticles show varying oxidizing capacities and injury potentials toward biological systems. Here, two metal oxide libraries including transition-metal-doped Co3O4 and PdO-Co3O4 with strong chemical contacts were design-synthesized and used to investigate their biological injury potential and mechanisms using zebrafish as a model organism. Among different dopants, Cu significantly increased the oxidizing capacity of Co3O4. An increased amount of PdO resulted in higher density of heterojunctions, which also led to higher oxidizing capacity. The oxidizing capacity of these nanoparticles was positively correlated with higher mortality of dechorionated embryos and severe larval skin injury upon exposure. Using transgenic zebrafish Tg(LysCeGFP), we show in real time that the redox-active nanoparticles induced skin injury and activated the infiltration of immune cells. Such inflammatory response was confirmed by the increased mRNA expression level of Nrf2a, HO-1, IL-1ß, and IL-6 genes. Although the exposure to the nanoparticles alone was not lethal, the skin injury did lower the tolerance level against other environmental contaminants. More importantly, after withdrawing from the nanoparticle exposure, larvae with skin injury could recover within 24 h in uncontaminated medium, indicating such injury was transient and recoverable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Nanopartículas del Metal Límite: Animals Idioma: En Revista: ACS Nano Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Nanopartículas del Metal Límite: Animals Idioma: En Revista: ACS Nano Año: 2020 Tipo del documento: Article País de afiliación: China