The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment.
Cancer Res
; 80(13): 2705-2717, 2020 07 01.
Article
en En
| MEDLINE
| ID: mdl-32193287
ABSTRACT
The extracellular matrix (ECM) surrounding cells is indispensable for regulating their behavior. The dynamics of ECM signaling are tightly controlled throughout growth and development. During tissue remodeling, matricellular proteins (MCP) are secreted into the ECM. These factors do not serve classical structural roles, but rather regulate matrix proteins and cell-matrix interactions to influence normal cellular functions. In the tumor microenvironment, it is becoming increasingly clear that aberrantly expressed MCPs can support multiple hallmarks of carcinogenesis by interacting with various cellular components that are coupled to an array of downstream signals. Moreover, MCPs also reorganize the biomechanical properties of the ECM to accommodate metastasis and tumor colonization. This realization is stimulating new research on MCPs as reliable and accessible biomarkers in cancer, as well as effective and selective therapeutic targets.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Comunicación Celular
/
Proteínas de la Matriz Extracelular
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Matriz Extracelular
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Microambiente Tumoral
/
Carcinogénesis
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Canadá