Associations between ideal blood pressure based on different BMI categories and stroke incidence.
J Hypertens
; 38(7): 1271-1277, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32195818
ABSTRACT
OBJECTIVES:
The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for high blood pressure (BP) in adults redefined hypertension as SBP at least 130âmmHg or DBP at least 80âmmHg. However, the optimal BP for different BMI population to reduce stroke incidence is uncertain.METHODS:
A prospective cohort study was designed by four examinations baseline (2004-2006), 2008, 2010 and 2017 follow-up. The study group composed of 36â352 individuals, to determine the ideal BP range to reduce stroke incidence of two BMI level, adjusted Cox proportional hazards models were utilized to establish the associations between SBP/DBP and the risk of stroke incident. Then, the restricted cubic spline regression was applied to find the ideal range of SBP/DBP values for two kinds of BMI categories definitions.RESULTS:
During a median follow-up period of 12.5 years, 2548 (7.0%) nonstroke individuals at baseline developed incident stroke. After fully adjusting confounding factors, SBP (per 20âmmHg increase) and DBP (per 10âmmHg increase) are independently associated with the risk of stroke incidence [SBP, hazard ratioâ=â1.277, 95% confidence interval (95% CI), 1.217-1.340, Pâ<â0.001; DBP, hazard ratioâ=â1.138, 95% CI, 1.090-1.189, Pâ<â0.001].CONCLUSION:
Our study revealed that the ideal BP for a population with BMI less than 24âkg/m was less than 130/80âmmHg, whereas the ideal BP for BMI at least 24âkg/m was less than 120/80âmmHg. The sensitivity analyses between BMI less than 25âkg/m and BMI at least 25âkg/m showed similar findings. This finding provides more accurate primary prevention strategies based on various BMI populations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Índice de Masa Corporal
/
Accidente Cerebrovascular
/
Hipertensión
Tipo de estudio:
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
/
Asia
Idioma:
En
Revista:
J Hypertens
Año:
2020
Tipo del documento:
Article