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Effects of Melatonin Administration to Pregnant Ewes under Heat-Stress Conditions, in Redox Status and Reproductive Outcome.
Bouroutzika, Efterpi; Kouretas, Dimitrios; Papadopoulos, Serafeim; Veskoukis, Aristidis S; Theodosiadou, Ekaterini; Makri, Sotiria; Paliouras, Charilaos; Michailidis, Marios-Lazaros; Caroprese, Mariangela; Valasi, Irene.
Afiliación
  • Bouroutzika E; Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
  • Kouretas D; Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, Mezourlo, 41500 Larissa, Greece.
  • Papadopoulos S; Department of Ichthyology and Aquatic Environment, University of Thessaly, Fytokou str., 38446 Volos, Greece.
  • Veskoukis AS; Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, Mezourlo, 41500 Larissa, Greece.
  • Theodosiadou E; Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
  • Makri S; Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, Mezourlo, 41500 Larissa, Greece.
  • Paliouras C; Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
  • Michailidis ML; Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
  • Caroprese M; Department of Sciences of Agriculture, Food and Environment (SAFE), University of Foggia, Via Napoli 25, 71122 Foggia, Italy.
  • Valasi I; Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
Antioxidants (Basel) ; 9(3)2020 Mar 23.
Article en En | MEDLINE | ID: mdl-32210209
Heat stress is a known promoter of reactive oxygen species generation, which may compromise pregnancy and foetal development. Melatonin is a pleiotropic molecule that regulates various processes including pregnancy. Thus, it could be used to ameliorate the redox status of pregnant heat-stressed ewes and the outcome of their pregnancy. Sixty-eight ewes participated in the study, which were allocated into two equal groups, i.e., Melatonin (M) and Control (C) group. All ewes were exposed to heat stress from D0 to D120. In both groups, after oestrus synchronization of ewes, rams were introduced to them for mating (D16). In M group, starting with sponges' insertion (D0), melatonin implants were administered four-fold every 40 days. Pregnancy diagnosis was performed by means of ultrasonography. Daily evaluation of temperature humidity index (THI), rectal temperature, and breathing rate were performed throughout the study. Blood samples were collected repeatedly from D0 until weaning for assaying redox biomarkers. Milk yield was measured thrice during puerperium. The results showed that melatonin administration throughout pregnancy improved the redox status of heat-stressed ewes and increased the mean number and bodyweight of lambs born per ewe, as well as the milk production. Therefore, melatonin may be used as antioxidant regimen in heat-stressed ewes for improving their reproductive traits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza