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Circular RNA profile in diabetic peripheral neuropathy: analysis of coexpression networks of circular RNAs and mRNAs.
Zhang, Hong-Hong; Zhang, Yilian; Wang, Xixi; Yang, Panpan; Zhang, Bing-Yu; Hu, Shufen; Xu, Guang-Yin; Hu, Ji.
Afiliación
  • Zhang HH; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
  • Zhang Y; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
  • Wang X; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
  • Yang P; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
  • Zhang BY; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
  • Hu S; Center for Translational Pain Medicine, Institute of Neuroscience, Soochow University, Suzhou, 215123, PR China.
  • Xu GY; Center for Translational Pain Medicine, Institute of Neuroscience, Soochow University, Suzhou, 215123, PR China.
  • Hu J; Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, PR China.
Epigenomics ; 12(10): 843-857, 2020 05.
Article en En | MEDLINE | ID: mdl-32212929
ABSTRACT

Aim:

To study the expression pattern of circular RNAs in diabetic peripheral neuropathy. Materials & 

methods:

Transmission electron microscopy was used to observe the ultrastructure of sciatic nerves and dorsal root ganglion (DRGs). circRNAs in DRGs were identified with high-throughput RNA sequencing. Whole-genome mRNAs were detected by a chip scan.

Results:

The ultrastructure of sciatic nerves and DRGs in diabetes mellitus mice changed significantly. A total of 11,004 circRNAs and 15 differentially expressed circRNAs, as well as 35,368 mRNAs and 133 differentially expressed mRNAs were identified in DRGs between wild-type and diabetes mellitus mice. 11 circRNAs and 14 mRNAs have a significant correlation using strict coexpression analysis. The expression of circRNA.4614 was validated to be upregulated significantly.

Conclusion:

Our study suggested that circRNAs might be involved in the regulation of mRNA expressions in diabetic peripheral neuropathy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Neuropatías Diabéticas / ARN Circular Límite: Animals Idioma: En Revista: Epigenomics Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Neuropatías Diabéticas / ARN Circular Límite: Animals Idioma: En Revista: Epigenomics Año: 2020 Tipo del documento: Article