Circular RNA profile in diabetic peripheral neuropathy: analysis of coexpression networks of circular RNAs and mRNAs.
Epigenomics
; 12(10): 843-857, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32212929
ABSTRACT
Aim:
To study the expression pattern of circular RNAs in diabetic peripheral neuropathy. Materials &methods:
Transmission electron microscopy was used to observe the ultrastructure of sciatic nerves and dorsal root ganglion (DRGs). circRNAs in DRGs were identified with high-throughput RNA sequencing. Whole-genome mRNAs were detected by a chip scan.Results:
The ultrastructure of sciatic nerves and DRGs in diabetes mellitus mice changed significantly. A total of 11,004 circRNAs and 15 differentially expressed circRNAs, as well as 35,368 mRNAs and 133 differentially expressed mRNAs were identified in DRGs between wild-type and diabetes mellitus mice. 11 circRNAs and 14 mRNAs have a significant correlation using strict coexpression analysis. The expression of circRNA.4614 was validated to be upregulated significantly.Conclusion:
Our study suggested that circRNAs might be involved in the regulation of mRNA expressions in diabetic peripheral neuropathy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Neuropatías Diabéticas
/
ARN Circular
Límite:
Animals
Idioma:
En
Revista:
Epigenomics
Año:
2020
Tipo del documento:
Article