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Inflammation and central adiposity as mediators of depression and uncontrolled diabetes in the study on global AGEing and adult health (SAGE).
Dona, Allison C; DeLouize, Alicia M; Eick, Geeta; Thiele, Elizabeth; Salinas Rodríguez, Aarón; Manrique Espinoza, Betty Soledad; Robledo, Ricardo; Villalpando, Salvador; Naidoo, Nirmala; Chatterji, Somnath; Kowal, Paul; Snodgrass, J Josh.
Afiliación
  • Dona AC; Department of Anthropology, University of Oregon, Eugene, Oregon, USA.
  • DeLouize AM; Department of Anthropology, University of Oregon, Eugene, Oregon, USA.
  • Eick G; Department of Anthropology, University of Oregon, Eugene, Oregon, USA.
  • Thiele E; Department of Biology, Vassar College, Poughkeepsie, New York, USA.
  • Salinas Rodríguez A; Centre for Evaluation Research and Surveys, National Institute of Public Health, Mexico.
  • Manrique Espinoza BS; Centre for Evaluation Research and Surveys, National Institute of Public Health, Mexico.
  • Robledo R; Nutrition and Health Investigation Center, National Institute of Public Health Laboratory, Cuernavaca, Morelos, Mexico.
  • Villalpando S; Nutrition and Health Investigation Center, National Institute of Public Health Laboratory, Cuernavaca, Morelos, Mexico.
  • Naidoo N; Department of Health Statistics and Information Systems, World Health Organization SAGE, Geneva, Switzerland.
  • Chatterji S; Department of Health Statistics and Information Systems, World Health Organization SAGE, Geneva, Switzerland.
  • Kowal P; Department of Anthropology, University of Oregon, Eugene, Oregon, USA.
  • Snodgrass JJ; Department of Health Statistics and Information Systems, World Health Organization SAGE, Geneva, Switzerland.
Am J Hum Biol ; 32(6): e23413, 2020 11.
Article en En | MEDLINE | ID: mdl-32222050
OBJECTIVES: Diabetes and depression are commonly present in the same individuals, suggesting the possibility of underlying shared physiological processes. Inflammation, as assessed with the biomarker C-reactive protein (CRP), has not consistently explained the observed relationship between diabetes and depression, although both are associated with inflammation and share proposed inflammatory mechanisms. Central adiposity has also been associated with both conditions, potentially by causing increased inflammation. This study uses the World Health Organization's Study on global AGEing and adult health (SAGE) Mexico Wave 1 biomarker data (n = 1831) to evaluate if inflammation and central adiposity mediate the relationship between depression and diabetes. METHODS: Depression was estimated using a behavior-based diagnostic algorithm, inflammation using venous dried blood spot (DBS) CRP, central adiposity using waist-to-height ratio (WHtR), and uncontrolled diabetes using venous DBS-glycated hemoglobin (HbA1c). RESULTS: The association between depression and uncontrolled diabetes was partially mediated by CRP before but not after WHtR was considered. When WHtR was added to the model, it partially mediated the relationship between diabetes and depression while fully mediating the relationship between depression and CRP. CONCLUSIONS: These findings suggest that central adiposity may be a more significant mediator between diabetes and depression than inflammation and account for the relationship between these disorders and inflammation. Depression may cause an increase in central adiposity, which then may lead to diabetes, but the increase in known systemic inflammatory pathways caused by central adiposity may not be the key pathological mechanism.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Diabetes Mellitus / Obesidad Abdominal / Inflamación Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Am J Hum Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Diabetes Mellitus / Obesidad Abdominal / Inflamación Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Am J Hum Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos