The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers.

Orjuela, Stephany; Menigatti, Mirco; Schraml, Peter; Kambakamba, Patryk; Robinson, Mark D; Marra, Giancarlo

Orjuela, Stephany; Menigatti, Mirco; Schraml, Peter; Kambakamba, Patryk; Robinson, Mark D; Marra, Giancarlo.

Afiliación

Orjuela S; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Menigatti M; Institute of Molecular Life Sciences, University of Zurich and SIB Swiss Institute of Bioinformatics, Zürich, Switzerland.
Schraml P; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Kambakamba P; Department of Pathology and Molecular Pathology, University of Zurich, Zürich, Switzerland.
Robinson MD; Division of Surgical Research, University of Zurich, Zürich, Switzerland.
Marra G; Institute of Molecular Life Sciences, University of Zurich and SIB Swiss Institute of Bioinformatics, Zürich, Switzerland.

BMC Cancer ; 20(1): 290, 2020 Apr 06.

Article en En | MEDLINE | ID: mdl-32252665

Asunto(s)

Biomarcadores de Tumor/genética; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/patología; Epigenoma; Neoplasias Hepáticas/secundario; Neoplasias Colorrectales/metabolismo; Epigénesis Genética; Secuenciación de Nucleótidos de Alto Rendimiento/métodos; Humanos; Captura por Microdisección con Láser/métodos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Fenotipo; Regiones Promotoras Genéticas

Palabras clave

Colorectal cancer; CpG islands; CpG sites; DNA methylation; Differentially methylated regions; Liver metastasis; MBD capture; Methyl-binding domain; Normal colorectal mucosa

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Epigenoma / Neoplasias Hepáticas Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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