Poly(ethylene glycol)-block-poly(4-vinyl pyridine) as a versatile block copolymer to prepare nanoaggregates of superparamagnetic iron oxide nanoparticles.
J Mater Chem B
; 2(11): 1565-1575, 2014 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-32261375
ABSTRACT
This work reports an efficient method for the preparation of aqueous dispersions of superparamagnetic iron oxide nanoparticles (SPIONs), involving the use of an amphiphilic block copolymer, poly(ethylene glycol)-block-poly(4-vinyl pyridine) (mPEG-b-P4VP). The iron oxide nanoparticles are easily and efficiently dispersed due to the strong direct interaction of the hydrophobic P4VP segments, through complexation with pyridine units of the copolymer. Well-defined block copolymers, having different compositions and molecular weights, were prepared by atom transfer radical polymerization (ATRP). The aqueous self-assembly behavior of each system has been compared based on the method of preparation. The results revealed that the addition of ionic species has a significant effect on the size and type of formed nanostructures, the magnitude of which is dependent on the block copolymers' molecular design. When similar self-assembly strategies were used in the presence of SPIONs, the same type of nanostructures was formed. The hybrid SPION nanoaggregates were investigated using NMR relaxometric techniques, whereby high r2/r1 relaxivity ratios were achieved, making these materials potentially efficient T2-weighted MRI contrast agents.
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01-internacional
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MEDLINE
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En
Revista:
J Mater Chem B
Año:
2014
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Article